Postdoc position - Deciphering the KMT9 biology in a preclinical colorectal cancer model (m/f/d)

Stellenbeschreibung

Anstellungsart

Vollzeit

Arbeitsort

79110 Freiburg

Vollständige Stellenbeschreibung

The lab of Dr. Eric Metzger at the Department of Urology, Medical Center – University of Freiburg, is offering a

Postdoc position - Deciphering the KMT9 biology in a preclinical colorectal cancer model (m/f/d)

The fully funded Postdoc position is available at the Center for Clinical Research, Medical Center, University of Freiburg, Germany. The group led by Dr. Eric Metzger is a multi-disciplinary team with a focus on all aspects of epigenetic regulation including immuno-oncology, stemness, metabolism, signaling, drug development, and chromatin states. The research group is embedded in the Collaborative Research Centre 1479, a research effort of 19 PIs on various aspects on oncogene-driven immune escape.

The Metzger lab combines genome-wide analyses and single cell-omics techniques with in vivo approaches such as genetically modified mouse and 3D organoid models to study the interdependent interaction between tumor and its microenvironment. The aim is to connect basic and translational research with comprehension of human diseases.

The proposed project aims to investigate the functions of the lysine methyltransferase KMT9 (Wang et al, Nat Commun, 2024, Berlin et al, Cancer Research 2022, Metzger et al, Nat Struc Mol Biol 2019) in reprogramming the tumor microenvironment in colorectal cancer. You will be part of a team, which combines genome-wide analyses, proteomics, metabolomics, and molecular- and cellular biology with epigenetic regulation to identify novel avenues for translation in clinical practice. In particular, we intersect immuno-oncology and immunological approaches with epigenetic information to develop novel therapeutic strategies orchestrating tumor-microenvironment interactions.

Applicants with experience in immuno-oncology and/or immunology are preferred.

We offer:

a dynamic, highly interactive environment and an international working atmosphere with state-of-the-art facilities

intensive support and interdisciplinary collaborations

a 2-year Postdoc position

Tasks:

perform genome-wide transcriptome (RNA-seq, scRNA-seq), cistrome (ChIP-seq, CUT&RUN) proteome analyses. Use technologies such as flow cytometry, CODEX imaging. Perfom bioinformatic analysis

work with mouse and human CRC organoids and preclinical mouse models

perform functional T-cell assays, immune checkpoint analyses, and signaling studies

Your Profile:

completed PhD in molecular medicine, biology, biochemistry, or a related field

experience in immuno-oncology and/or immunology

interest in translational cancer immunology

independent, structured work style and good English skills

To apply, please open the link 'Apply online', fill out the online application form, and attach all your materials in English in one PDF file. The application should consist of an up to date CV, a supporting statement, which describes why you would be a suitable candidate for the position, and at least two letters of recommendation.

Your complete online application must be submitted no later than 13th of April (23:59 German time).

Questions? Then send us an email:

General information: Salary is assigned according to a pay scale. Unless prevented by operational or legal reasons, full-time positions are generally open to those wishing to job share. Where two candidates are equally suitable for a post, severely disabled candidates are given priority. Employment decisions are made by the Personnel Department.

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