Technical Assistant (m/f/x)

TUD Dresden University of Technology, as a University of Excellence, is one of the leading and most dynamic research institutions in the country. Founded in 1828, today it is a globally oriented, regionally anchored top university as it focuses on the grand challenges of the 21st century. It develops innovative solutions for the worlds most pressing issues. In research and academic programs, the university unites the natural and engineering sciences with the humanities, social sciences and medicine. This wide range of disciplines is a special feature, facilitating interdisciplinarity and transfer of science to society. As a modern employer, it offers attractive working conditions to all employees in teaching, research, technology and administration. The goal is to promote and develop their individual abilities while empowering everyone to reach their full potential. TUD embodies a university culture that is characterized by cosmopolitanism, mutual appreciation, thriving innovation and active participation. For TUD diversity is an essential feature and a quality criterion of an excellent university. Accordingly, we welcome all applicants who would like to commit themselves, their achievements and productivity to the success of the whole institution.

The Center for Regenerative Therapies Dresden (CRTD), an institute of the Center for Molecular and Cellular Bioengineering (CMCB), the Chair of iPS Cells and Neurodegenerative Diseases (Prof. Dr. Jared Sterneckert) is looking for a highly motivated and talented

Technical assistant (m/f/x)

(subject to personal qualification employees are remunerated according to salary group E 9a TV-L)

starting as soon as possible. The project position comprises 75% of the full-time weekly hours and is limited to 24 months (time limitation pursuant to TzBfG).

Tasks: Characterizing mouse neurodegenerative disease models

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-associated neurodegenerative diseases. We have imported two mouse models of ALS/FTD, and we aim to better characterize the mouse models, including by performing immunofluorescence on spinal cord sections to count motor neurons and assess neuroinflammation, ventral root to count axon number, neuromuscular junctions to assess denervation of skeletal muscle, and protein aggregation in motor neurons. These mice will be characterized for motor and cognitive behavior using assays available at our institute. Once established, these mouse models will be used to characterize the efficacy of novel therapeutics, including by AAV-based gene therapeutics aimed at reducing the expression levels of disease-causing mRNAs. Explicit tasks are e.g.: Mouse genotyping, Sample preparation and processing via cryosectioning, Immunofluorescence, Fluorescence microscopy, and assisting in overall laboratory organization.

Requirements: We aim at attracting the best talent and expect the following:

completed vocational training as a biological-technical assistant (BTA), chemical-technical assistant (CTA) with several years of professional experience or as biological/chemical laboratory technician with equivalent knowledge and experience

a FELASA certificate as well as a minimum of six months experience working with laboratory mice

experience with immunohistochemistry and/or immunofluorescence is highly desired

ability to work in an international team is essential

inter- and multidisciplinary thinking

high motivation

an integrative and cooperative