Research Intern - Biosensing Assay Optimization and Characterization (Team BDB)

Research Intern - Biosensing Assay Optimization and Characterization (Team BDB)

About BioMed X

BioMed X is an independent research institute with sites in Heidelberg, Germany, New Haven, Connecticut, XSeed Labs in Ridgefield, Connecticut, and a worldwide network of partner locations. Together with our partners, we identify big biomedical research challenges and provide creative solutions by combining global crowdsourcing with local incubation of the worlds brightest early-career research talents. Each of the highly diverse research teams at BioMed X has access to state-of-the-art research infrastructure and is continuously guided by experienced mentors from academia and industry. At BioMed X, we combine the best of two worlds – academia and industry – and enable breakthrough innovation by making biomedical research more efficient, more agile, and more fun.

About Team BDB

The objective of the group Advanced Biomarker Detection for Pharmacological Monitoring in the Brain (BDB), headed by Dr. Khulan Sergelen is to develop an in vivo continuous monitoring biosensor for direct detection of small molecule biomarkers in brain tissue of rodent models for elucidating pharmacodynamic (PD) effect and pharmacokinetic (PK) parameters of drugs against neuropsychiatric diseases. Our team will explore the multifaceted task of continuous monitoring biosensor development, including molecular design and assay development, biocompatible sensor architecture, and optical sensor integration for in vivo monitoring.

The Position

We are seeking a masters student (10-20 hours/week, 6-12 months – internship or masters thesis) to conduct research on 'Optimization and Characterization of Biosensing Assays.' The ideal candidate should have a background in Biotechnology, Materials Science & Engineering, Biochemistry, or a related field, with an interest in biosensors. Experience with analytical techniques and/or knowledge of molecular interaction kinetics is preferred.

The project involves developing biosensor assays and designing biosensing utilizing DNA aptamers for analyte quantification. The student will have the opportunity to perform surface plasmon resonance (SPR) and multiparametric SPR (MP-SPR) measurements to produce molecular interaction studies for analyte sensing. This endeavor will provide hands-on experience with various laboratory techniques, including surface plasmon resonance (SPR), fluorescence microscopy, and other molecular biology techniques depending on the students interests.

How to Apply

If you are interested in the position, please submit your application by e-mail before May 31, 2024 to the attention of Dr. Cátia Santa () or Dr. Khulan Sergelen ().

Applicants will be interviewed upon incoming documents, hence please get in touch as soon as you decide to apply.

Contact

BioMed X Institute

Im Neuenheimer Feld 515

69120 Heidelberg

Germany

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