PhD Student (m/f/d)

The Institute of Anatomy and Cell Biology, Department of Molecular Embryology at the Albert-Ludwigs-University Freiburg is looking for the research group of Prof. Dr. Christian Schachtrup at the earliest possible date for a

PhD Student (m/f/d)

Our research focuses on the molecular and cellular mechanisms that govern central nervous system (CNS) repair and regeneration. In particular, we study how blood–brain barrier disruption alters the local tissue environment to drive scar formation and impair functional recovery (Akassoglou et al., 2024, Cell; Nath et al., 2024, Nat Commun; Martinez Santamaria et al., 2025, iScience).

Specifically, we investigate how changes in vascular permeability with vascular-derived factors regulate reactive gliosis and fibrotic scar formation, and how these barriers influence neural stem cell behavior, differentiation, and function.

The PhD student will investigate the cellular and molecular mechanisms that regulate fibroblast–immune cell interactions at CNS interfaces following vascular dysfunction.

The successful candidate will be trained in a wide array of state-of-the-art techniques in modern neuroscience and molecular biology, including cell fate mapping using reporter mice, flow cytometry, single-cell RNA sequencing, advanced microscopy, and approaches in cell biology, signaling, and regenerative medicine.

Requirements:

above-average degree (Masters or equivalent) in molecular medicine, biology, chemistry, neuroscience, or a related natural science field

strong interest in neurobiology, vascular biology, and regenerative medicine

proven ability for independent and structured scientific work

ideally experience with modern molecular and cellular biology techniques (e.g., flow cytometry, single-cell RNA sequencing, advanced microscopy)

prior experience with animal models is advantageous but not mandatory

strong communication skills, motivation, and ability to work in an interdisciplinary team

We offer you:

a challenging and exciting research project in a dynamic and international research group

access to state-of-the-art research facilities and cutting-edge technologies

an inspiring academic environment at the University of Freiburg

opportunities for international networking and scientific exchange

structured doctoral training and mentoring

The position is limited to 3 years. Depending on qualifications and the tasks assigned, remuneration will be based on TV-L E13.

Are you interested in a varied and responsible field of activity? Please send us your documents exclusively via our online portal by 30.06.2026.

Albert-Ludwigs-Universität Freiburg

Institute of Anatomy and Cell Biology

Department of Molecular Embryology

Prof. Dr. Christian Schachtrup

Albertstr. 17, 79104 Freiburg

Questions? Then give us a call or send an e-mail:

Prof. Dr. Christian Schachtrup

0761/203-5101

Please do not send any application documents to this e-mail address.