PostDoc (f/m/d)

Link: (CompanyWebsite)

Gegründet: 1994 (CompanyFounded)

Mitarbeiteranzahl: 5.001 bis 10.000 (CompanyEmployee)

Branche: Gesundheitswesen (CompanyIndustry)

Stellenbeschreibung

Anstellungsart

Vollzeit

Arbeitsort

37075 Göttingen

Vollständige Stellenbeschreibung

Ihre Aufgaben

Investigate the molecular mechanisms and organelle pathology underlying lysosomal diseases (endo-lysosomal trafficking, autophagy, secondary mitochondria disruption)

Apply and integrate multi-OMICS (transcriptomics, proteomics, metabolomics) approaches to identify dysregulated intracellular pathways and identify therapeutic targets

Validate targets using genetic and pharmacological perturbations (CRISPR/ Cas9, small molecules) with quantitative functional readouts (enzyme activity, lysosomal flux, imaging)

Maintain and characterize patient-derived fibroblasts and iPSC models; implement disease-relevant phenotypic assays

Develop and automate high-throughput compatible assays for drug repurposing screenings; analyze hits and lead follow-up studies

Collaborate across our Göttingen network; document, present, and publish results; and contribute to reproducible workflows and data sharing initiatives

Ihre Qualifikationen

PhD (completed or near completion) in life sciences (e.g., biology, molecular medicine, biochemistry) or a related discipline

Strong hands-on background in molecular and cell biology with an interest in translational medicine

Experience in gene editing, multi-omics data integration, basic program ming, or advanced imaging is desirable

Experience with high-throughput/automation and stem cell (IPSC) models is an advantage, but not mandatory, as these skills can also be developed during the project

High self-motivation, an independent and creative working style, and excellent teamwork and communication skills

[SL1]Right term for developing python scripts for automated readout and analysis?

Wir bieten

A collaborative neuroscience and translational research environment at the University Medical Center Göttingen (UMG), DZKJ, and Fraunhofer ITMP, with close ties to leading institutions such as the Max Planck Institute for Multidisciplinary Sciences and the DZNE

Extensive opportunities for interdisciplinary exchange, joint projects, and direct links between basic and clinical research through local, national, and international collaborations • Secure, multi-source funding (UMG, EU programs, patient organizations, DZKJ) supporting ambitious, long-term projects

Attractive UMG employee benefits, including on-site daycare and vacation childcare, robust health and sports programs, modern infrastructure, and professional development opportunities

A beautiful, historic university town with an exceptional concentration of research institutes (University of Göttingen, Max Planck Institutes, German Primate Center, Fraunhofer Institute, German Centers for Health Research (DZG)) and a high quality of life

Einleitungstext

We are seeking a motivated researcher to investigate the molecular pathophysiology of lysosomal and related neurodegenerative diseases and to contribute to the development of novel therapeutic approaches. Lysosomal diseases are rare, neurometabolic disorders that often manifest in childhood or adolescence. Despite their genetic heterogeneity, many share converging molecular mechanisms that overlap with classical adult-onset neurodegenerative diseases. These disorders affect both the nervous system and peripheral organs and are clinically characterized by pr