Doctoral Researchers (f/m/x)

We are looking to support our rapidly growing team as soon as possible two:

Doctoral Researchers (f/m/x)

Institut für Radiochemie und Experimentelle Molekulare Bildgebung

TV-L: 25 h/week (64,94%)

limited for 2 years according to WissZeitVG. Following this period, the successful candidate is expected to continue for at least one additional year at INM-5, Forschungszentrum Jülich.

Your salary will be based on TV-L EG 13

Your tasks

Your future with us

Organic synthesis of precursor and reference compounds for the development of novel PET tracers for imaging estrogen receptors in the brain Synthesis and structural modification of steroidal and non-steroidal estrogen receptor ligands Development, optimization and performance of radiofluorination reactions for the preparation of 18Flabeled PET tracers Investigation and optimization of radiochemical reaction conditions with regard to yield, reproducibility, molar activity and radiochemical purity Analytical and radiochemical characterization of the prepared compounds using HPLC, radio-HPLC, TLC/radio-TLC, MS and NMR Determination of relevant physicochemical and radiopharmaceutical properties, e.g. lipophilicity, stability and metabolite profiles Contribution to the establishment and documentation of suitable quality control and synthesis protocols Support in the automation of selected radiosyntheses and in the preparation of translational synthesis and quality control strategies

We are one of the leading university hospitals in Germany and network research, teaching and health care at the highest level. Thats why many things are a lot bigger for us: the spectrum of exciting development opportunities. The limitless openness with which specialists from all over the world work together here. Or our commitment as an employer to support all employees as best we can in reconciling their job with their goals and life situations.

This is the University Hospital of Cologne: Everything but ordinary.

Your future in detail

The University of Cologne offers a broad spectrum of academic disciplines and internationally outstanding research areas across its six faculties. At the Faculty of Medicine, numerous scientists are engaged in research, teaching and patient care across a wide range of clinics, institutes and centers. The Faculty of Medicine and the University Hospital Cologne are part of the highly active Rhineland research region and closely collaborate with numerous university and nonuniversity partners. This strong network enables

Support of the biological and preclinical evaluation of tracer candidates, e.g., in in vitro assays, stability and binding studies, BBB models, ex vivo analyses and in vivo imaging studies Analysis, documentation and scientific presentation of experimental results in project reports, publications and presentations

Your profile

Completed Masters or Diploma degree in chemistry, pharmacy, biochemistry, molecular biotechnology or a related natural science Sound knowledge of organic synthesis chemistry and preparative laboratory work Experience in the synthesis and characterization of bioactive molecules, ligands or radiopharmaceutical precursor compounds is advantageous Experience in radiochemistry, radiosynthesis and/or work with short-lived radionuclides, in particular fluorine-18, is desirable but not mandatory Experience in the application of analytical methods such as HPLC, LC-MS, NMR and TLC Interest in radiopharmaceutical tracer development, molecular imaging and translational