Postdoctoral Researcher in Cell-State Plasticity in Gliomas (m/w/d)

Das UKB verbindet als eines der leistungsstärksten Universitätsklinika Deutschlands Höchstleistungen in Medizin und Forschung mit exzellenter Lehre. Jährlich werden am UKB über eine halbe Million Patienten ambulant und stationär versorgt. Hier studieren rund 3.500 Menschen Medizin und Zahnmedizin, zudem werden jährlich über 600 Personen in Gesundheitsberufen ausgebildet. Mit rund 9.900 Beschäftigten ist das UKB der drittgrößte Arbeitgeber in der Region Bonn/Rhein-Sieg. In der Focus-Klinikliste belegt das UKB Platz 1 unter den Universitätsklinika in NRW und weist unter den Universitätsklinika bundesweit den zweithöchsten Case-Mix-Index (Fallschweregrad) auf. 2024 konnte das UKB knapp 100 Mio. € an Drittmitteln für Forschung, Entwicklung und Lehre einwerben. Das F.A.Z.-Institut zeichnete das UKB im vierten Jahr in Folge als „Deutschlands Ausbildungs-Champion“ und „Deutschlands begehrtesten Arbeitgeber“ aus.

Wissenschaft und Forschung

Vollzeit

Postdoctoral Researcher in Cell-State Plasticity in Gliomas (m/w/d)

ST-47008

The Department of Neuro-Oncology at the University Hospital Bonn is seeking to fill the following full-time position (38.5 hours/week) at the earliest possible date:

Postdoctoral Researcher in Cell-State Plasticity in Gliomas (m/w/d)

The position is initially limited to a fixed term of two years.

Our newly established Experimental Neuro-Oncology group at the University Hospital Bonn (UKB) (PI: Prof. Sevin Turcan) investigates how genetic and epigenetic alterations drive brain tumor initiation, progression and therapy resistance. A major focus of the lab is IDH-mutant glioma, where we aim to understand how oncometabolite-driven epigenetic reprogramming creates persistent tumor cell states and how these states evolve during malignant progression and recurrence.

The successful candidate will lead a flagship project at the interface of tumor genomics, chromatin biology, functional perturbation and cell-state plasticity. The project builds on our labs previous work on IDH mutant gliomas and will combine patient-derived glioma models, tumor genomics, DNA methylation and chromatin profiling, selected single-cell/spatial technologies, and functional validation approaches.

This position is initially limited to 2 years, with the possibility of extension.

Application

Please submit your application as a single PDF, including:

a cover letter describing your scientific interests and motivation for joining the lab

a curriculum vitae including publication list

contact details for two to three referees

Ihre Aufgaben

Lead an independent research project on tumor genomics, epigenetic plasticity and cell-state evolution in IDH-mutant gliomas

Design and perform molecular and functional experiments, including perturbation of candidate epigenetic, transcriptional or signaling regulators

Generate and interpret tumor genomic and epigenomic datasets, such as DNA methylation, RNA-seq, ATAC-seq, CUT&Tag/CUT&RUN or targeted single-cell/nuclei-based readouts

Integrate experimental data with computational collaborators to identify mechanisms that stabilize malignant cell states and nominate actionable vulnerabilities

Contribute to the development of a long-term research program on IDH-mutant glioma evolution, epigenetic memory and therapeutic state rewriting

Prepare manuscripts, present results at national and international conferences, and contribute to grant applications

Support the supervision and training of junior lab members,