Postdoc (all genders) in intestinal immunity / section Regenerative Medicine and Immunology

CD4+ T cells are key regulators of host-defense against pathogens, more recent studies by our group have shown that CD4+ T cells importantly regulate tissue (re)generation in humans. During the lifespan the immune system faces time-window dependent challenges characterized by changes in microbial and virus exposure and tissue growth, resulting in an increased risk of infectious and immune-mediated diseases e.g. early in life and adolescence, especially upon exposure to infectious, metabolic or endocrine stressors. In this project the role of endocrine dysregulation in disruption of fetal organ immune development through epigenetic modifications and subsequent susceptibility of inflammatory bowel disease are investigated. The studies build on analyses of observational studies including several single cell omics and computational analyses and innovative human intestinal tissue-based organoid systems to decipher the molecular interactions between immune cells and parenchymal cells in tissue (re) generation and inflammation. The goal is to understand critical developmental programs regulating intestinal immune development and identify pathways that can be targeted to restore tissue homeostasis. Your tasks: Experimental studies of intestinal organoid systems and immune cells, including planning of experimental design, experiments, documentation and statistical analysis of results; interpretation, discussion and presentation of results Computational analyses of high dimensional data, including flow cytometry, scRNAseq and spatial transcriptomics Scientific publishing, presentation at international conferences, communitty outreach Our Offer Fair and transparent compensation in accordance with our collective bargaining agreement (TVöD/VKA / TV-Ärzte/VKA) (€ 63,600 - € 91,100), taking into account qualifications and professional experience. The salary range applies to a full-time position of 38.5 hours per week. The amounts listed are guidelines and do not constitute a salary guarantee. Targeted and individualized professional development at both the technical and project levels is provided, offering long-term prospects in a meaningful work environment Comprehensive continuing education and training programs at our UKE Academy for Education and Career Opportunities to help shape our “UKE INside” personnel policy through cross-functional and cross-hierarchical projects Sustainable commuting: Subsidies for the Deutschlandticket as a job ticket and Dr. Bike bicycle service Excellent health, prevention, and sports programs Family-friendly work environment: Partnerships for childcare, free vacation care, counseling for employees with family members requiring care A secure job, meaningful work, and a supportive team environment Structured onboarding and open knowledge sharing within the team Our employee restaurant offers a wide variety of culinary options; additional options are available at the “Health Kitchen” cafés and bistros and at a supermarket located directly on the premises Your Profile Completed scientific university degree and preferably a PhD in biology, biochemistry, or a related field, or a medical degree with a clinical-scientific background Training in (tissue) immunology or infectious diseases Expertise in computational analyses of various OMICS data sets 2 letters of recommendation from former mentors Strong interest in pursuing research in academia We look much forward to receiving your application, includin