PhD Position in T Cell Immunology

PhD Position in T Cell Immunology

23.09.2024, Wissenschaftliches Personal

The research group of Prof. Marc Schmidt-Supprian at the Institute of Experimental Hematology is seeking a highly motivated PhD student starting from now onwards. The research project focuses on regulatory T (Treg) cells and investigating their context-specific identity and function in B cell-driven autoimmune diseases. This collaborative project is embedded in the Transregional Collaborative Research Centre TRR 355 and is funded for three years.

Project Overview:

The candidate will contribute to a collaborative DFG-funded project aimed at understanding the identity and plasticity of regulatory T (Treg) cells, in the context of autoimmunity. The primary objectives include:

• to compare central Treg cell identity and function programs between mice and men in normal physiology and autoimmunity in collaboration with project partners

• elucidate the transcriptional networks regulated by FoxP3 and c-Rel in Treg cells and screen for novel critical regulators of Treg identity and function in autoimmune contexts

• study how context-specific cytokine milieus affect Treg identity as well as plasticity and functionally validate engineered Treg cells with distinct anti- or pro-inflammatory features

Key Responsibilities:

• Conduct wet lab experiments to generate data describing the context-dependent Treg identity and underlying transcriptional networks.

• Collaborate with project partners.

• Contribute to the preparation and analysis of data for publication and presentations.

The following qualifications will be of advantage but are not stringently required at start:

• Strong background in T cell biology/immunology.

• Hands-on experience with transgenic mouse models, including breeding and colony management.

• Proficiency in preparing and processing lymphoid organs from mice.

• Expertise in Flow Cytometry, particularly in multi-color FACS staining and cell population analysis.

• Experience/Interest in single cell RNA sequencing experiments.

• Excellent proficiency in English, both written and spoken.

This is a unique opportunity to contribute to high-impact research in a collaborative and interdisciplinary environment. If you are passionate about T cell immunology and eager to work on a dynamic project, we encourage you to apply.

Contact:

Prof. Dr. Marc Schmidt-Supprian

Klinikum rechts der Isar

Technische Universität München

TranslaTUM

Einsteinstr. 25

81675 München

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