PhD Candidate in Functional Genomics and Pancreatic Cancer Research; part time 65% (m/w/d)

PhD Candidate in Functional Genomics and Pancreatic Cancer Research; part time 65% (m/f/d)

PhD Candidate in Functional Genomics and Pancreatic Cancer Research; part time 65%

(m/f/d)

Workplace

Campus Großhadern

Working hours

Part time

Institution

Medizinische Klinik II (Gastroenterologie und Hepatologie)

Department

Doktorarbeit Forschungslabor

Date of entry

At the earliest possible date

Application deadline

01.10.2026

Reference Number

2026-K-0328

The Hospital of the University of Munich, Germany, is one of the largest and most competitive university hospitals in Germany and Europe. 48 specialized hospitals, departments and institutions harbouring excellent research and education provide patient care at the highest medical level with around 12.000 employees.

Scope of duties

Work on the project “Global mapping of drug synergy landscapes using massively parallel Cas13d genetic interaction screening” within the German Cancer Aid-funded DEFEAT-PDAC consortium

Investigate therapeutically relevant genetic dependencies and drug combinations in pancreatic ductal adenocarcinoma

Perform and analyze high-throughput genetic interaction screens, particularly using Cas13d-based screening approaches

Plan and conduct molecular and cell biological experiments to validate identified targets and drug synergies

Investigate rational combination therapies, including combinations with RAS/KRAS inhibitors

Work with pancreatic cancer cell lines and additional preclinical model systems

Apply modern methods in cell biology, molecular biology, functional genomics and proteomics

Quantitatively analyze, interpret and document experimental data

Collaborate closely with research groups and technology platforms within the DEFEAT-PDAC network

Present research findings at project meetings and scientific conferences and contribute to scientific publications

Our requirements

A successfully completed university degree, preferably a Masters degree or equivalent, in biology, biochemistry, molecular medicine, biotechnology or a related life-science discipline

Strong interest in cancer biology, functional genomics, mechanisms of therapy resistance and translational cancer research

Practical experience in cell and molecular biology, for example mammalian cell culture, transfection, RNA and protein analysis, immunoblotting or microscopy

Previous experience with CRISPR-based technologies, genetic screens, proteomics, next-generation sequencing or bioinformatic data analysis is an advantage, but not mandatory

Motivation to learn new experimental technologies and quantitative analysis methods

A careful, structured and independent approach to scientific work

Scientific curiosity, high motivation and enthusiasm for experimental research

Strong communication and teamwork skills and an interest in working in an interdisciplinary and international research environment

Very good written and spoken English

German language skills are not required

Our offer

An innovative and challenging PhD project within the DEFEAT-PDAC consortium, a national and internationally connected research network funded by German Cancer Aid

An international and interdisciplinary research environment at the interface of cancer biology, functional genomics, proteomics and clinical translation

State-of-the-art laboratories and access to advanced screening, proteomics, sequencing and data-analysis platforms

Close collaboration with basic scientists, bioinformaticians and clinician scientists

Structured scient