Postdoctoral Researcher Neuroimmunology

Postdoctoral Researcher Neuroimmunology

Specialty

Neurology

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Work time

full-time

Start date

01.12.2026

Employment period

limited

Application deadline

10.10.2026

Deployment location Charité

Campus Charité Mitte

Jobcode

8219

Salary group

E13

Working at Charité

We are seeking a highly motivated Postdoctoral Researcher with a strong background in human immunology and single-cell immune profiling. This role offers an exciting opportunity to work at the interface between the clinic and the laboratory, in a dynamic and international team studying antibody-mediated and autoimmune diseases of the nervous system. We follow patients over time and combine longitudinal sampling with single-cell immunology, antibody cloning and translational immunotherapy, which makes questions accessible that are usually out of reach in human disease.

The antibody & brain lab is deliberately interdisciplinary. Clinicians, laboratory scientists and bioinformaticians work in the same group, and the lab maintains its own computational arm covering antibody structure prediction, machine learning and immune repertoire analysis. You can find out more about the team and its research at antibodybrainlab.com.

The successful candidate will take responsibility for the single-cell analysis of paired cerebrospinal fluid and blood lymphocyte populations across the groups projects and will develop their own scientific line within this field. The position offers substantial scientific independence, access to a prospective patient cohort with ongoing recruitment, and the opportunity to shape a translational research programme from patient sample to molecular mechanism.

Overview of the position

Take ownership of the groups single-cell workflow, from sample processing and sorting strategy through to data analysis and interpretation.

Develop and optimise multicolour flow cytometry panels for lymphocyte populations in low-input clinical material, and perform cell sorting.

Generate single-cell datasets from paired CSF and blood samples, including transcriptome and paired BCR/TCR repertoire data.

Integrate flow cytometry, transcriptomic and repertoire data to characterise disease-associated lymphocyte populations and clonal dynamics over time.

Develop and pursue an independent research question within the groups scientific focus, for example on the emergence of autoimmunity following infection of the central nervous system.

Present findings at international conferences and lead manuscript preparation.

Supervise doctoral and medical students within the team.

What we are looking for

PhD in Immunology, Neuroscience, Systems Biology, Molecular Biology or a related discipline; strong background in immunology, in particular adaptive immune responses

Extensive hands-on experience with primary human immune cells and proven expertise in multicolour or spectral flow cytometry, including panel design, optimisation, cell sorting and data analysis

Hands-on experience with single-cell technologies, including scRNA-seq and immune repertoire sequencing, covering sample processing, sorting strategy and preparation of samples for sequencing

Independent analysis of single-cell datasets in R or Python (e.g. Seurat, Scanpy), including quality control, integration, clustering, cell type annotation and differential expression

Excellent organisational skills, the ability to run several projects in parallel, and fluency in spoken and written English; German is not required.

Desirabl