Bioinformatician (f/m/d) for Epigenetic Networks in Aging and Cancer

Bioinformatician (f/m/d) for Epigenetic Networks in Aging and Cancer

postdoctoral position

Operational area: Helmholtz Institute for Biomedical Engineering -Institute for Stem Cell Biology-

Working hours: 100% of the collectively agreed full-time working hours (currently 38.5 hours per week)

Duration/Term of employment: Initially limited to 2,5 years.

Start date: 01.10.2026

Remuneration/Rates: EG 13 (TV-L)

Within the project “Transform-Me” (supported by the Else Kröner-Fresenius Stiftung), we are investigating how epigenetic changes, particularly DNA methylation patterns, are coordinated across the genome. We anticipate these modifications are coherently modified in trans within epigenetic networks. We want to identify modules and hubs that are co-regulated in aging, development, and particularly in malignant transformation. Furthermore, we aim to modulate these epigenetic networks by epigenetic editing. We are looking for a bioinformatician with a strong background in epigenetic characterization of cell preparations with focus on DNA methylation. We are integrating own and public EPIC Illumina Bead Chip datasets, RNA-seq, ATAC-seq, ChIP-seq, nanopore, and single cell DNAm sequencing datasets.

You can find further information on our research group under:

References: Liesenfelder et al., 2025:

Varona Baranda et al., 2026:

Your tasks:

Integrative analysis of many epigenetic datasets, particularly DNAm profiles from public repositories

Coregulation and network analysis

Machine learning approaches predicting epigenetic patterns

Analysis and integration of chromatin accessibility and histone modifications

Analysis of single cell DNAm datasets

Design and analysis of epigenetic editing experiments

Scientific publication of the results

Your profile:

Masters degree in either Biology, Bioinformatics, or comparable degrees in Natural Sciences

A successful PhD with bioinformatics on epigenetics or stem cell research

Bioinformatic skills for DNA methylation analysis

programming languages R and optionally perl or python

Knowledge in cancer and aging research

Willingness to contribute to different projects within our team

Able to communicate clearly in English and willing to work in an international team

Relevant scientific publications

Why you should choose us?

We offer…

We provide a highly interactive and well-equipped environment, in an international team, with excellent partners

The research topic is very timely, clinically relevant, and challenging

30 days of vacation per year for full-time employment

Application:

The application deadline for the advertised position GB-P-56328 is August 30, 2026.

Plesae include:

a motivation letter, which specifically emphasizes your interest in this project

CV with publication list

contacts of two references

copies of the most important certificates (with grades)

University Hospital of the RWTH Aachen, Helmholtz Institute for Biomedical Engineering -Institute for Stem Cell Biology-, Head of Division Prof. Wolfgang Wagner, M.D., Ph.D, Pauwelsstr. 30, 52074 Aachen.

Contact:

If you have any questions, please contact Prof. Dr. Dr. Wolfgang Wagner ( ) or Katharina Hayat ( )

We look forward to receive your application.

This job advertisement is aimed at all genders.

The RWTH Aachen University Hospital promotes equal opportunity and diversity. Applications from women are expressly sought and, in accordance with relevant laws, will be treated preferentially.

We welcome applications from people with disabilit